Diagnosing and Treating Autonomic Disorder at Stanford Marc Laderrieres story

My name is Marc Laderriere. Born and raisedin France. I livedPaso Robles, for the last 10 years. I work a lot. You know, less exercise, youknow, you paying less attention, and then, the one day you realize, hey, I'm a littletired, what's going on, you know? Also, we noticed, that I was sweating very,very little, and I was very susceptible to heat, and I would basically get very, verytired and like hit a wall. After multiple series of blood test throughthe local s, we decided to go to Stanford to see what we could do.

Mr. Laderriere was referred to us really becauseof the fatigue, but also because his primary care physician noticed that his blood pressurewas changing quite a bit. When we examined himthe , a few things were striking.First, his pupillary reaction was not as we expected and his skin was unusually y andwe happened to evaluate him here during a very hot day. So, he clearly had issues withperspiration. And then, we measured his blood pressure again and we had him lay down forabout 10 minutes, stood him up and there was a persistent ophis blood pressure. Jaradeh pretty much right away felt, itprobably was something that had to do with

the autonomic nervous system. The autonomic nervous system is the part ofthe nervous system that controls all the vital functions and the organs that are independentof our own will. For instance, the reason why your heart beats is independent of yourwill. The range of the autonomic disorders can befairly wide, as you might expect. The most common problems we find are first problemsin patients who cannot stay upright very long. Sometimes, patients present with unexplainedarrhythmias where the heart, you know, palpitates like crazy, the other presentation usually,is patients who have major digestive issues.

Then, heat tolerance can be a problem, becauseif somebody cannot sweat, it's really difficult for them to be outthe heat, they can developheat stroke fairly quickly. Testing these patients requires an integratedapproach, which is not availablemany areas. During the first meeting, he asked, quot;Haveyou ever been treated for Lyme Disease?quot; and I said, quot;Absolutely not.quot; So, we went throughthat right away, and of course, we discovered right then that, I had Lyme Disease for probably5 to 10 years. So, he, wanted me to be on antibiotics, toeradie the different markers of Lyme Disease. Now, I do not have any more Lyme Disease.But it was clear, however, that I did have

a autonomic nervous disorder of sorts. We believe that we found the cause and we'retrying to adess it. And then, we basically worked with him a regimen where we give himmediion that could help him with the sweating function, andfact, he has noticed somebenefit from that. We also started giving him mediion that, attenuate, or completelyeliminate, hopefully, the ophis blood pressure, and we'll watch and see how he does. He definitely has all the information andhe deals with, obviously, more difficult cases. I think we probably have stabilized his conditionat this point. I seems pretty confined, and

fact, couple of signs may be better. I'm fairly optimistic I think he will regainmore functionthe next two years, I feelgood hands, there's no doubt.