Fluoroquinolones and Peripheral Neuropathy

Peripheral neuropathy, this is an often devastatingconditionwhich people develop pain and numbnesstheir hands and feet. Basicallythey're told on the evening news that they should be taking this or that mediion sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know thatAmerica,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic amatically increases yourrisk for having peripheral neuropathy and

fact being devastated by it. This is adisease that effects 115 Americans. Let's take a look. So again this is 115 Americans—thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month,the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory

infections and even urinary tract infections.Things like Levaquin and Cipro are commonly usedwalks. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study publishedSeptember2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodandthis group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of

antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolonesthe United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these ugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most

well respected peer journals is nowtelling us that the use of these mediions—these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep thatmind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.

Short Term Side Effects of Chemotherapy

David Margileth, MD: One of the major concernswith women going on chemotherapy is the question, what are the shortterm side effects? So let'sdiscuss what those are and what we try to do about them. The shortterm side effects that women worrymost about is nausea and vomiting. With the new antinausea medicines that we use intravenouslyprior to each chemotherapy such as ugs like Aloxi or Emend have made nausea and vomiting90% less than they used to be. So, patients are, for the most part, pleasantly surprisedthat nausea and vomiting is not a major issue. The other issue is infections, and if we areon a chemotherapy that causes low white counts,

we have ugs such as Neulasta and Neupogenthat will keep those white counts normal and thus avoid infectious compliions and potentialization. Other effects, fatigue can be an issue. Obviously, hair loss on somechemotherapies can be an issue. Toward the middle or the end of some chemotherapies withugs known as Taxanes, peripheral neuropathy can become an issue and that is numbness andtingling of the fingers and toes, and we don't want that to progress to more nerve damage,so that is something on a longer regimen with Taxol or Taxotere, we always ask, are youhaving numbness and tingling and if so we will modify the regimen so that the patientdoes not end up with a long term peripheral

neuropathy. Mouth sores or these ulcerlikesores that we used to commonly see with chemotherapy really are not much of an issue anymore withNeulasta. So, those are the major things and I think most women are again pleasantly surprisedthat this is not nearly as awful as they think it is going to be.

What does ganciclovir mean

What does ganciclovir mean? ganciclovir. Noun 1. An antiviral mediion used to treat or prevent cytomegalovirus infections.