Fluoroquinolones and Peripheral Neuropathy

Peripheral neuropathy, this is an often devastatingconditionwhich people develop pain and numbnesstheir hands and feet. Basicallythey're told on the evening news that they should be taking this or that mediion sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know thatAmerica,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic amatically increases yourrisk for having peripheral neuropathy and

fact being devastated by it. This is adisease that effects 115 Americans. Let's take a look. So again this is 115 Americans—thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month,the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory

infections and even urinary tract infections.Things like Levaquin and Cipro are commonly usedwalks. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study publishedSeptember2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodandthis group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of

antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolonesthe United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these ugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most

well respected peer journals is nowtelling us that the use of these mediions—these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep thatmind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.

Bulletproof Radio QA 191

Dave: Hi, everyone. It�s Dave Asprey withBulletproof Radio. Today�s cool fact of the day is that it�s no secret I love fatbut there�s new research that says even high fat diets can be brain protective. Thetheory behind this research is that fat particularly mediumchain triglycerides gives the brainenough energy to trigger selfrepair, the idea that your brain cells like ketones especiallythe neurons, that it may give them the ability to repair themselves more. We don�t knowthis for sure. It�s just intriguing research but it�s cool. Today�s episode is oneof my favorite kinds and one of your favorite kinds too because it�s a Q and A episode.We get so many questionsonline and I don�t

do these as often as I would like becauseI really like the opportunity to do themperson with someone else rather than overSkype. If you�re watching this live, you probablynoticed that I�m notmy normal studio. That�s because I�m here at Tampa at JJVirgins Mindshare event. She brings together about a huned successful health influencers,people who are working to make everyone around us healthier. I�m honored to be here butit gave me an excuse to hang out with my buddy, Zak. Zak is going to run through a bunch ofyour questions that you�ve submitted on Facebook, on YouTube and on our blog postsjust at the very bottom of the blog. If it�s

a podcast blog, there�s a form that youcan use to submit questions. If you�re listening to this and you want to get one of your questionsanswered, submit it there and we track these things. Then, every time Zak and I sit downtogether, we go through and I�ll answer them for you to the best of my ability. Allright, Zak. Let�s do it, man. Zak: All right. Our first question comes fromBodjie. He says, �Hi, Dave. I�ve been using your products for the last six monthsnow. I just want to ask what is the difference between MCT oil, XCT oil and brain octane? Dave: This is a thinly veiled � This isactually a question from someone? This isn�t

like a marketing question? Zak: Actually, we got a bunch of the samequestions. People want to know. Dave: Good. MCTs are, if you look at thisfrom a marketing perspective, there�s four kinds of MCTs. The coconut oil companies willsay, �Oh, look. This is 62% MCT,� but they�re lying to you because the richestsocalled MCT that�scoconut oil is called lauric acid. It�s the predominant fattyacid like that. In coconut oil, there�s just one problem. It doesn�t get processedby the liver like a mediumchain triglyceride. It gets processed like a longchain triglyceride.You can get away with selling lauric acid

as a mediumchain triglyceride even thoughit�s a lie. It�s not a mediumchain triglyceride. It doesn�t work that way. Now, lauric acid�sgood for you but it�s dirt cheap. It�s called eat coconut oil because half of coconutoil is lauric acid. I recommend eating coconut oil as a way to get that one MCT. There�s four kinds of MCTs that differentcompanies will try and sell us as real MCT just like coconut oil companies but you�renot getting the purest stuff that we�re using from metabolic activation. Now, that�splain MCT. There�s also problems with just normal commodity MCT that had to do with somethingcalled C17. I wrote about thisthe Bulletproof

Diet book. C17 is an odd chain fat that�smade by less pure processes. If you�ve ever had severe disaster pants after using commodityMCT, there�s a reason for that. Some of it comes from cosmetic machines. Some of it�simported from China but most of it has the C17 which causes the gastro distress. It happens.You get much less of that from XCT oil. Now, XCT oil is the two shortest lengths.It�s not all four of the MCTs. It�s just two of them. It�s the C8 and the C10. XCToil which we usually call the upgraded MCT oil, that stuff is distilled an extra timemore than normal MCTs that you�d find on the market. It�s that extra step of distillationand filtering that gets rid of the C17 and