Fluoroquinolones and Peripheral Neuropathy

Peripheral neuropathy, this is an often devastatingconditionwhich people develop pain and numbnesstheir hands and feet. Basicallythey're told on the evening news that they should be taking this or that mediion sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know thatAmerica,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic amatically increases yourrisk for having peripheral neuropathy and

fact being devastated by it. This is adisease that effects 115 Americans. Let's take a look. So again this is 115 Americans—thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month,the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory

infections and even urinary tract infections.Things like Levaquin and Cipro are commonly usedwalks. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study publishedSeptember2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodandthis group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of

antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolonesthe United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these ugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most

well respected peer journals is nowtelling us that the use of these mediions—these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep thatmind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.

A Journey Through A Stem Cell Transplant for Amyloidosis at Boston Medical Center

music music music music music Diane is such a great person the most selfless person I've even metmy entire life nurse talking

never complains never not once did she ever complain the words of quit fail and can't are nother vocabulary well she is probably the strongest and one of the biggest fighters that I knowwhen we now when we found out it really um shook us all up because

Di isn't just my sister my best friend she's the family rock story begins with purple eyes my family are hockey players so most people most people just assumed I took a hockey puckthe eye but a biopsy showed i had a very rare noncurable disease hello and welcome to theMassachusetts School of Law eduional forum produced by theMassachusetts School of Law At Andover I'm Diane Sullivan you're host for today's program Being Irish I have the curse of very fair skin so each year I visit my skin

finkel was concerned over my bruised eyelids but I explained to him they had been previously checked and a biopsy showed nothing abnormalthis is just how they are I said no diane said finkel, this is not normalthe biopsy showed nothing I responded again sometimes he said it depends on who reads ita few days later finkel was on the phone it was then I heardabout the disease amyloidosis the first time and I quickly learned

this was not good though the amyloidosis diseases are actually a set of diseasesthat can be blood or bone marrow disordersthemost common form but there are also genetic diseases and diseases that occursecondary to other conditions like chronic infections and chronicinflammatory diseases so they really span a broad spectrum of medical care andfact we've developed a multidisciplinary program to take care ofpatients with amyloidosis but my interest iswhat really is themost common type

amyloidosisthe United States withwhich is AL amyloidosis also known as primary amyloidosis and the same appliesto Sanchorawala so we are hematologists andbecause that particular form is a blood disorderover many decades research here and elsewherewe learn that these diseases can be treated with chemotherapy to affect cellsthe bonemarrow and we consider the disease to be acousin of a more common