Peripheral Neuropathy Symptoms Resolved DavisSpineInstitute
When you first presented to the office, youpresented with chronic low back, leg pain, and neuropathy pain in your legs and feet.Your post surgical fusion patient and you had utilized a lot of different forms of therapyin pain management before coming to our office for help. How did you do with our therapyand how are you feeling today? Great, I don't have the pain down my leg, I have feelingin my feet now, I don't have that constant pain in the back. Well congratulations. We'revery proud of your results, and we're very proud to have you has a patient. Thank you.
Neural circuitry of cognitive disorders
My group, forthe last 40 years, has been interested in solving complex human problems,and the problems that I have felt arethe most important are really problems that haveto do with human behavior. And with respect to thebrain, our major interests are really in approaching someof the toughest problems that affect our society, both asa society and as individuals,
which are mentalillness, anxiety, hopefully some newinsights into autism, and both pro andantisocial behavior. We all know that Down'ssyndrome is due very simply to an extra chromosome, soinstead of 46 chromosomes, they have 47 chromosomes. So there we are. Somewhere over 200 genes,but that's still 200 genes,
so how do we narrow downto know what the genes are, and HeavenstoBetsy, howare we going to know how they were linked to thedevelopment of the brain? So what I have done in my group,and developed the techniques to do this molecularly,is to, sort of, pull apart chromosome 21 and tobegin to assign small subsets, slices of the chromosome toparticular problems whether it's being small of stature,whether it's having problems
with being able to visualizethings, or to read, or to have behavioral problems,or speech problems which are a major problem. And one of the thingsthat really pulls on your heartstrings, but it shouldpull on your heartstrings, is that we have apair of identical twins, one of whom has Down's syndrome,and one of whom doesn't. The family is spectacular.
The kidsthey'reboysare spectacular. And from the comparisons,the detailed comparisons of their genes, the expression,and their brain structure, a whole new worldis opening up to us. So we study them, not onlytheir brain and their MRIs, we study them attheir cellular levels, and when we understandtheir cellular pathways, the specificity of that, bingo.
We can focus in on what'swrong and how we might fix it. The University of Utah is one ofthe most wonderful places I have had the privilege tobe a scientist. Why? Because we have one of themost collaborative faculties, not only at theUniversity of Utah, but at the State, at BYU. It has been a wonderfulexperience to collaborate. When I set up a newprogram, the response I get is,
The Monetary Cost of Dementia
It looks like we've underestimated the monetarycost of dementiaâ€”really the impact of dementia on our society. People seem to be focusedon various forms of cancer, and certainly focused on heart disease, but it turns outthat at least from a monetary perspective, we're spending far more on dealing with dementiathan those other two categories. And this was recently looked at and published lastyearâ€”2013â€”in the New England Journal of Medicine. Let's take at the report. This is a summary from a study actually carriedout during the year 2010, published in 2013, a study carried out by the RAND Corporationthat found that the prevalence of dementia
in America is about 14.7% of the populationover age 70 years, making it basically an epidemic. Now we're spending around $50,000dollars each year to care for demented patients, around $200 billion dollars in America todeal with dementia. That compares to heart disease, which is about half that number:$100 billion, and care of cancer patients, about $77 billion, or about 13 of what we'respending on dementia. I think it's very important in this day andage when we do not have any pharmaceutical treatment for dementia to take a step backand look at what might be causing this epidemic. And it turns out blood sugar is playing avery important roll, and even the metabolism
of the brain in the areas that are relatedto Alzheimers in terms of their utilization of blood sugar is really very important. Let'shave a look at another study. This is a study published in the Journal ofNeurology, and it looks at the ability of the brain to function in comparison to fastingblood sugar. What it found was when looking at particular areas of the brain that areinvolved with Alzheimers, the parietal lobe, for example, and the temporal regions, thatthese areas functioned much worse when blood sugar was even mildly elevated. This is avery dramatic graph showing decreased function of critical brain areas happening just becausethe blood sugar is elevated. What the authors
concluded, and I quote, quot;This study providesadditional evidence for the relationship between high fasting serum glucose levels and thepredisposition to Alzheimers disease. It suggests that, in cognitively normal older adults withouta history of diabetes, higher serum glucose levels may be a risk factor for Alzheimersdisease that may be unrelated toquot; certain genetic types of predispositions. This is very clear evidence that dementia,which I began this tutorial by telling you is costing us $200 billion dollars a yearâ€”notto mention the emotional tollâ€”is related to blood sugar. We control our blood sugarbased upon foods that we choose to consume.
And that's why we're all over the notion oflowering carbohydrates and keeping sugar off the plate. Eat more fat, it's good for yourbrain. I'm David Perlmutter.