Fluoroquinolones and Peripheral Neuropathy
Peripheral neuropathy, this is an often devastatingcondition in which people develop pain and numbness in their hands and feet. Basicallythey're told on the evening news that they should be taking this or that medication sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know that in America,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic dramatically increases yourrisk for having peripheral neuropathy and
in fact being devastated by it. This is adisease that effects 1 in 15 Americans. Let's take a look. So again this is 1 in 15 Americansâ€”thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month, in the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory
infections and even urinary tract infections.Things like Levaquin and Cipro are commonly used in walk in s. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study published in September2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodand in this group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of
antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolones in the United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these drugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most
well respected peer review journals is nowtelling us that the use of these medicationsâ€”these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep that in mind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.
Ask Anything On Call with the Prairie Doc Jan 28 2016
gt;gt; YOU ASK THE QUESTIONS, NEXT quot;ON CALL WITH THE PRAIRIE DOC.quot; gt;gt; GOOD EVENING, AND WELCOME TO quot;ON CALL WITH THE PRAIRIE DOC.quot; TONIGHT WILL BE OUR FIRST quot;ASK ANYTHINGquot; PROGRAM IN A WHILE. YOU ARE WELCOME TO CALL IN ABOUT, WELL, ANYTHING, BUT WE MAY TRY TO FOCUS A BIT ON INFECTIOUS DISEASES AND NEUROLOGY. ACCORDING TO OUR EXPERTS, BUT THEY'RE BOTH INTERNISTS. OKAY, LET'S TAKE A LOOK AT THIS WEEK'S PRAIRIE DOC QUIZ QUESTION. IN 2013, WORLDWIDE, AN ESTIMATED 500,000 PEOPLE DIED OF MALARIA, MOSTLY CHILDREN ON THE AFRICAN CONTINENT. THE QUESTION, TRUE OR FALSE, THERE ARE 1,500 CASES OF MALARIA DIAGNOSED IN THE UNITED STATES EACH YEAR. TRUE OR FALSE?
VIEWERS WHO CALL IN THE CORRECT ANSWER WILL BE ENTERED INTO A DRAWING TO WIN A SIGNED COPY OF quot;A PICTURE OF HEALTH.quot; THIS BOOK WAS WRITTEN BY ME, WITH WONDERFUL ACCOMPANYING PHOTOGRAPHS BY DR. JUDITH PETERSON. WE WILL ANNOUNCE THE ANSWER AND THE WINNER AT THE END OF THE SHOW. REMEMBER, YOU ONLY HAVE 10 MINUTES TO GET YOUR ANSWER IN! WE ANSWER YOUR MEDICAL QUESTIONS AND WE NEED YOUR QUESTIONS AS THEY'RE CALLED IN, SO PLEASE GIVE US YOUR CALL. SEND THEM VIA Facebook OR EMAIL OR CALL IN YOUR QUESTIONS TO 18883766225 OR SEND US AN EMAIL.
TONIGHT I HAVE THE PLEASURE TO WELCOME BACK SOMEONE I'VE KNOWN FOR MANY YEARS WHO HAS BEEN AN INSPIRATION TO ME. JOINING US TONIGHT IS DR. KENNETH WALKER, NEUROLOGIST AND A GREAT EDUCATOR, MY MENTOR, WHO BROUGHT ALONG INFECTIOUS DISEASE SPECIALIST ARCHIL UNDILASHVILI, BOTH FROM THE EMORY MEDICAL CENTER IN ATLANTA. KEN, WELCOME BACK. TELL US A LITTLE BIT ABOUT YOUR BACKGROUND. I MEAN, YOU WERE THE INTERNAL MEDICINE RESIDENCY DIRECTOR AND THE GUY WHO HIRED ME WHEN I WAS ON THE FACULTY FOR THREE YEARS. AND I CAN'T TELL YOU HOW MUCH I APPRECIATE THAT WONDERFUL THREE YEARS' EXPERIENCE, BEING ON THE FACULTY AT EMORY. HAVE I EVER THANKED YOU ENOUGH FOR THAT ONE?gt;gt; NO. gt;gt; I'LL BUY YOU A GLASS OF WINE LATER OR SOMETHING.
BUT TELL US A LITTLE BIT BUT WHERE YOU'RE FROM, YOU'RE FROM A FARM IN GEORGIA, RIGHT? gt;gt; GREW UP ON A TINY, LITTLE 109ACRE FARM. PROBABLY NOT UNLIKE A FAIR NUMBER OF FARMS OUT HERE IN SOUTH DAKOTA. CHICKEN, COTTON, COWS, PEANUTS, HORSES, ET CETERA. HAD TO GET UP AT 4:00 A.M. EVERY MORNING AND GO OUT AND MILK TEN COWS AND AT 7:00 CATCH A SCHOOL BUS. SO, WHEN I WAS 16, I WENT AWAY TO EMORY TO HIGH SCHOOL. AND I'VE STAYED THERE EVER SINCE, EXCEPT FOR TWO YEARS IN VIETNAM AS A PHYSICIAN IN THE MILITARY. AND I BECAME THE PROGRAM DIRECTOR AT EMORY UNIVERSITY, PROGRAM DIRECTOR, INTERNAL MEDICINE, FOR 30 YEARS.
I WAS HEAD OF MEDICAL EDUCATION FOR THE DEPARTMENT OF MEDICINE FOR 30 YEARS. I RAN THE SERVICE, THE MEDICAL SERVICE AT GRADY HOSPITAL, WHICH IS ONE OF THE HUGE INNERCITY HOSPITALS IN THE WORLD, FOR 30 YEARS. AND, SO, BASICALLY THAT'S MY BACKGROUND. I REMEMBER SO WELL, I THINK YOU WENT TO MEDICAL SCHOOL THE FIRST TWO YEARS IN SOUTH DAKOTA. gt;gt; YEAH. gt;gt; AND THEN YOU CAME TO US AS A JUNIOR. AND I REMEMBER HAVING BEEN TOLD BY THE DEAN TO BE ON THE LOOKOUT FOR THIS GUY FROM SOUTH DAKOTA THAT WE'RE NOT SURE WHETHER HE'S GOOD, BAD, OR INDIFFERENT. AND IT WAS MY PLEASURE, DISCOVERED THAT YOU WERE EXCELLENT,
AND WE KEPT YOU ON THE FACULTY, IT WAS OUR GREAT PLEASURE TO DO SO. gt;gt; THANK YOU FOR THAT. AND, AS A NEUROLOGIST, WERE YOU A NEUROLOGIST WHEN YOU WERE IN THE COMBAT UNIT, SORT OF THE M.A.S.H. UNITS IN VIETNAM? gt;gt; NO, I WAS IN INTERNAL MEDICINE THEN. I CAME BACK AND THEN BECAME A NEUROLOGIST. gt;gt; WOW. gt;gt; AND SOMEWHERE ALONG THE LINE, ACHICO, NICKNAME FOR ARCHIL, RIGHT OR ARCHICO. gt;gt; NO, IT'S A NICKNAME, LET'S LEAVE IT AT THAT. gt;gt; HOW DID YOU TWO MEET? gt;gt; WELL, I MET WALKER WHEN I WORKED IN THE INFECTIOUS DISEASE HOSPITAL.