Small Fiber Neuropathy Symptoms Diagnosis and Treatment
Small fiber neuropathy is really an interestingcondition because it consists typically of just burning, numbness, pain of the feet,sometimes the hands later on without necessarily having any abnormalities on your EMG or nerveconduction study. So what I tell patients and actually residents or students who trainunder us is that a normal nerve conduction study does not exclude a neuropathy. And wewill confirm this by doing additional testing, specifically the nervous the the examinationat the bedside asking patients about their symptoms, for example, loss of sensation tocool or or hot temperatures, loss of pain sensation and also doing skin biopsies wherewe look at nerve densities in the skin both
from the calf and the thigh as well as doinga special test that looks at sweat function both in your foot in in the legs as well asthe feet to gauge the level of small fiber nerve damage. Small fiber neuropathy typicallywill progress unless the underlying cause is identified and reversed. Diabetes of coursebeing the most common cause is always screened for. But once the more common causes are excludedand the focus becomes on excluding any underlying secondary disease process but also controllingpain because if patients' symptoms of pain are generally controlled they tend to do prettywell and really have no other major functional deficits. I've really become interested overthe years is how interconnected neurology
and rheumatology are and one thing I oftendo on patients who have unexplained small fiber even autonomic neuropathy is have themsee rheumatology or get evaluated for connective tissue disorders like lupus or Sjogren's orsarcoid and sometimes even if we are not directly involved in treating the patients, this canbe the first sign of an underlying connective tissue disorder that can then be brought tothe attention of rheumatology and addressed from their standpoint.
Peripheral Nervous System Disorders Diagnosis and Treatment
The peripheral nervous system is the partof the nervous system that excludes or is outside of the brain and the spinal cord.We take care of patients that have disorders that affect the motor neurons, which livein the spinal cord â€“ the peripheral nerves that extend out into the arms and legs aswell as the muscles and the connection between the nerves and the muscles. Some of the disordersthat a nerve and muscle a disease specialist will evaluate and develop care plans for includemuscle disorders such as muscular dystrophy, polymyositis, dermatomyositis, peripheralneuropathies such as Charcot Marie Tooth disease or hereditary neuropathy and as well as theneuromuscular junction disorders such as myasthenia
gravis. Some symptoms that can be associatedwith the peripheral nervous system include generalized weakness, fatigue, numbness, tingling,sometimes pain can be caused by disorders of the peripheral nerve. The evaluation ofa patient with a possible peripheral nervous system disorder first begins with the verycareful history to understand how the symptoms started and how they affect the patient. Fromthe history we extend to the physical exam, which helps us determine what sort of deficitsmay be impacting the patient's function. From there we design a targeted testing strategyto to try to pinpoint exactly what's causing the symptoms. It's a very exciting time inneuromuscular medicine because the more we
understand about how these diseases occur,the more that we can develop very targeted, personalized treatments to help either stopor reverse the disease. In many cases there may not be a specific cure but we can reducethe symptoms through a comprehensive treatment plan.
Seeing Pain New approach to diagnosing and treating nerve damage Chris McCurdy TEDxUM
When I was a young childI lost my favorite uncle to alcohol abuse. It made me wonder why does this happen? How can someone be consumed by a substance that's around us all the time? So, I made it my life's missionto become a drug expert, and I went to pharmacy school. I went to pharmacy schoolto understand what it is about drugs
that can make us heal or can hurt us. When I was in pharmacy school, I found out I fell in lovewith the research. Not only did I fall in lovewith the research I fell in love with this passionto educate others. And so, knowing that,I had to move forward. I had to move forward with my education so that I could carry those thingsout of my future;
and I went on and earned a atein medicinal chemistry; that's drug design not designer drugs. (Laughter) That enabled me to move forward and really pursue some of the basisof drug abuse and addiction. Here I am now, a professorof medicinal chemistry and pharmacology. And I've dedicated my careerto solving problems in drug abuse and actually findingbetter pain medications
because after all, painis the most common reason that individuals seek medical care. It's also the most common reason that we end upwith drug abuse and addiction. Moving from there, I've been ableto establish a laboratory here, at the University of Mississippi, where we've done a lotof groundbreaking work that I'll get to in a little bit to move us forward in those endeavors.
Now, how many people here have had to seek medical treatment that resulted in pain prescription? Yes, most all of us. How many of you ended up getting something like morphine, or codeine,or Hydrocodone, or Oxycontin? Yeah. Any of you had to take that for more than 2 or 3 weeks,maybe a month, maybe a couple?
If so, there's a high likelihoodyour body became physically dependent. So why does that mean? What do we mean when we talkabout physical dependence and drug abuse? Let's define these thingsa little more clearly. So drug abuse is simply the concept that you take a drug out of the contextthat it was prescribed. So, every now and then,all of us are guilty of taking a little more ibuprofen,or something, than it says on the bottle.