Fluoroquinolones and Peripheral Neuropathy
Peripheral neuropathy, this is an often devastatingconditionwhich people develop pain and numbnesstheir hands and feet. Basicallythey're told on the evening news that they should be taking this or that mediion sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know thatAmerica,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic amatically increases yourrisk for having peripheral neuropathy and
fact being devastated by it. This is adisease that effects 115 Americans. Let's take a look. So again this is 115 Americansâ€”thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month,the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory
infections and even urinary tract infections.Things like Levaquin and Cipro are commonly usedwalks. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study publishedSeptember2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodandthis group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of
antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolonesthe United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these ugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most
well respected peer journals is nowtelling us that the use of these mediionsâ€”these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep thatmind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.
Scientific approach requires scientific experiment! CMT: scientific approach, nutrition, health, supplements, work outs. Hello my friends! My name is Tsatsulin Boris, you are on my YouTube channel, called CMT, scientific approach, and today we will talk about the hangover and how to deal with this unpleasant thing. There are many effective and ineffective tools to quickly understandwhose apartment you are. Someone offers you treat yourself by milk of Buffalo, someone advised you to ink mix of raw egg and brandy.
But what says science and medicinethis regard? Are there any really effective methods, how to minimize the problems? Today we will not talk about negative effects of alcohol. I have collected for you the latest researches about medical methods of getting rid of a hangover. This information is not existingyet. It is exclusive. When I started to search the info for this tutorial, I discovered much unsubstantiated information about appliion of the various ugs. There are more than 20 different medicine for hangover, pills, syrups and etc. This can be confusing for us.
Let's first find out what is a hangover? Guys, please be patience. The first part of the tutorial will tell about the mechanisms, that cause hangovers. It is necessary to know for everyone. When we know the causes of something, it is getting easier for us to understand, which methods will work well and which not. For those, who has a headache, andhurry, you can look through the timecodes, whichthe comments below. So! A hangover is when the brush does not fityour mouth because it is brush for the shoes))). Hangover is the result of the alcohol's impact on our body. Sometimes people write that quot;the scientific name of a hangover abstinence synomequot; This is not true!
Abstinence synome a painful condition because of the absence of a new dose of the ug, including alcohol, only if a person is sick with alcoholism. Hangover this heavy state of organism, expressedheadache, nausea and vomiting, indigestion, hand tremors, weakness, increase or decreaseblood pressure, and general malaise. Moreover, healthy person, after a heavy inking bout will be disgusted, if he will have thought about inking, it is normal, but if it does not happen, this person has highly chance to become an alcoholic. You will not believe me, but the processes, that lead out body to the hangover,
is still poorly understood by science. We have small number or researches. very small. And it is a bit strange, it is an occasion to think about it to lovers of worldwide conspiracy . How does the alcohol impact on the person? The first thing that happens to alcohol, when it enters into the liver, it ss transformation (oxidation) to acetaldehyde. This work for enzyme, which called alcohol dehyogenase. This acetaldehyde the most toxic component which could be created by processing of alcohol. It is poison. The faster the body will produce its detoxifiion; the sooner you will feel better.
This is the first step. Second step is converting acetaldehyde to acetic acid. Acetic acid is safe. This process also takes place mainlythe liver, but only with the help of using the enzyme, called aldehyde dehyogenase. Here, alcohol degradedthe blood, but a lot of acetaldehyde causes of hangover. Because of big amount of alcohol, enzymes system,the blood cannot complete the full conversion of acetaldehyde to acetic acid. After that begins the hangover 1,2. We ink too fast. The liver cannot cope with it.
Autonomic Nervous System Crash Course AP 13
No matter what you're a fan of, you canprobably think of two characters who fit the description. Holmes and Watson. Brennan andBooth. Kirk and Spock. Ron and Hermione. They're close. They understand each otherin ways that others don't, and you really can't picture one without the other. But when whenhappens, they usually reactdifferent ways. Like, if you're snooping around Hogwartsat night, and you come across some beastie, the smart money's on Hermione to come upwith a spell that saves the day, while Ron probably standin' there with his mouth open. And when Sherlock starts to go crazy becausethere hasn't been a fiendishly clever jewel
heist or whatever for him to figure out, youcan count on Watson to calm him down. Mostly. My brother John, who is a writer of books,will tell you that these characters are foils they're not opposites, exactly. They'recontrasts, and the more you see them together, the more they seem to complement or roundone another out. And that is basically your autonomic nervoussystema nutshell. Your autonomic system is the branch of yourperipheral nervous system that regulates the functions of your internal organs, like yourheart and stomach, and also controls your smooth and cardiac muscles, and your glands.
All things that you you do not consciously control, so,yes, you could say it has a lot of power over you. But the funny or maybe confusing thingabout this system is that its effects on your organs and muscles and glands are by no meansconsistent. Not at all. At any given moment, whether you happen tobe totally relaxed or completely flipping your wig, your autonomic system is constantlymaking involuntary, finetuned adjustments to your body, based on what signals your centralnervous system is picking up. This could mean changing your body temperature,sending extra blood to a particular area,
slowing your heart beat, or tweaking yourstomach secretions. Its effects change, depending on the situationyou're and also which part of your autonomic system ischarge at that moment. Because this weird little corner of your nervoussystem that keeps you alive is actually run by two coming interests. Two divisions that serve the same organs,but they create opposite effectsthem, battling it out back and forth, to eitherexcite your body's functions or subdue them. One of them is dedied to amping you upand preparing you for activity that's
your sympathetic nervous system. And the otherone talks you down and effectively undoes what its foil did. And that is the parasympatheticnervous system. Together, they're what make your body experiencestress, fear, relaxation, and defiance. Courage and cowardice. Panic and peace. If there's an epic novel going onyour body rightnow it is probably being written by these two. Let's talk about names for a minute. One of the two divisions of your autonomicnervous system is called the sympathetic system. That sounds kinda nice, doesn't it? It'slike understanding, and calming, and telling
you that it's not so bad after all. WRONG! Contrary to its comforting name, thesympathetic system is what sounds your internal alarm bells. It's the hardware behind thefamous â€œfight or flightâ€� response. It is synonymous with stress. If the sympathetic is for â€œfight or flight,â€�the parasympathetic is for â€œresting and digestingâ€� it's responsible for maintainingyour body and conserving energy for later. I recognize that this is confusing. But, when you explore the anatomy of thesetwo systems, like we're gonna do today,