Most Common Cause Of Peripheral Neuropathy Worldwide

Fluoroquinolones and Peripheral Neuropathy

Peripheral neuropathy, this is an often devastatingcondition in which people develop pain and numbness in their hands and feet. Basicallythey're told on the evening news that they should be taking this or that medication sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know that in America,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic dramatically increases yourrisk for having peripheral neuropathy and

in fact being devastated by it. This is adisease that effects 1 in 15 Americans. Let's take a look. So again this is 1 in 15 Americans—thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month, in the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory

infections and even urinary tract infections.Things like Levaquin and Cipro are commonly used in walk in s. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study published in September2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodand in this group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of

antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolones in the United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these drugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most

well respected peer review journals is nowtelling us that the use of these medications—these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep that in mind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.

Eva Feldman MD Tutorial Profile

gt;gt; Eva Feldman: So when I completedcollege I had the dilemma whether I wanted to go straight into medical school or whetherI also wanted to do research because when I was in college, I got very excited about thebrain and had, again a professor who told me that he felt that in the next centuryall the major advances in medicine and in research we're going to be in thenervous system particularly in the brain. So when I finished college, I decidedoh maybe I'll get a PhD and a M.D. And so I started my graduatestudies first and I began in a neuroscience program atthe University of Michigan.

Fell in love with the brain completely and whenI started medical school there was no doubt from the very first day inmedical school, I said I was going to be a neurologist and I loved every day of it. One of my passions as a neurologistis also to be a neuroscientist. So I'm very privileged to have a fairlylarge laboratory that I work in with about 30 young people who do research with me. And we've become very interested overthe last 5 years in using stem cells in regenerative medicine particularly inneurodegenerative diseases in neurology.

Lou Gehrig's disease is onepassion that we have. We're also interested in Alzheimer's disease,Parkinson's disease, and Huntington's disease. So from our basic findings in the laboratory ofhow stem cells can promote nerve regeneration and protect nerve cells from dying, we'veactually begun a al trial using stem cells in patients with Lou Gehrig's disease. So it's very exciting because what I do in mybasic science laboratory I can then transition over to my al practice and ALS or LouGehrig's disease is one of the disorders that I am familiar with and I take care ofhundreds of patients with that disorder.

And so I'm able to serve as a bridgefrom the basic science to the . I can go to the and tell my patients whatI've learned in my basic science laboratory. I can go back and tell my basicscientists what my patients have taught us and they teach us so much. And so stem cells is one of the majoravenues I see translating in the near future from my laboratory to a realal and therapeutic, I hope, option for patients with Lou Gehrig's disease.

Category: Neuropathic Pain

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