Fluoroquinolones and Peripheral Neuropathy
Peripheral neuropathy, this is an often devastatingconditionwhich people develop pain and numbnesstheir hands and feet. Basicallythey're told on the evening news that they should be taking this or that mediion sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know thatAmerica,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic amatically increases yourrisk for having peripheral neuropathy and
fact being devastated by it. This is adisease that effects 115 Americans. Let's take a look. So again this is 115 Americansâ€”thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month,the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory
infections and even urinary tract infections.Things like Levaquin and Cipro are commonly usedwalks. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study publishedSeptember2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodandthis group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of
antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolonesthe United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these ugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most
well respected peer journals is nowtelling us that the use of these mediionsâ€”these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep thatmind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.
Introducing NIH PersonCentered Outcome Tools
WELCOME TO THE LONG AWAITED LAUNCH OF THE PATIENT CENTERED OUT COME TOOLS HERE AT THE NATIONAL INSTITUTES OF HEALTH. I AM SUSANA SERRATESTEIN. I AM THE DIRECTOR OF THE DIVISION OF AT NIAMS, BUT I AM ALSO THE PROJECT OFFICER FOR THE
PATIENTREPORTED OUT COME MEASUREMENT INFORMATION SYSTEM, OTHERWISE KNOWN AS PROMIS. AND IT IS MY PLEASURE TO INTRODUCE THE PATIENT CENTERED OUT COME TOOLS TO THE NIH HERE TODAY. I WOULD LIKE TO TAKE A MOMENT TO
THANK ALL THE CENTER DIRECTORS WHO ARE HERE. THE NIH LEADERSHIP HAS ALL ALONG SINCE THE BEGINNING OF MANY OF THESE PROJECTS BACK IN THE 2002 TO 2004 PERIOD SHOWN TREMENDOUS LEADERSHIP, SUPPORT AND COMMIT PIMENTS TO THESE TOOLS WHICH ARE
ESSENTIAL TO MEASURE PATIENTREPORTED OUTCOMES IN CHRONIC DISEASES. THEY WILL INTRODUCE TO YOU THE COMPONENTS OF THE MANY OF THE COMPONENTS THAT COMPRISE WHAT WE ARE NOW CALLING PATIENTCENTERED OUTCOME TOOLS.
I WOULD ALSO LIKE TO THANK THE TEAM AT NORTHWESTERN UNIVERSITY, DR. RICHARD GERSHON, KAREN COOK AND MONICA FOR COMING ALL THE WAY FROM CHICAGO TO MAKE THE PRESENTATION TODAY, AND ESPECIALLY I WOULD LIKE TO THANK THEM FOR OFFERING THE TRAINING
OPPORTUNITY THIS SESSION THIS AFTERNOON. I KNOW A LOT OF PEOPLE HAVE REGISTERED FOR THAT, SO WE ARE EXCITED THAT THERE IS SO MUCH INTEREST ABOUT LEARNING HOW TO USE THESE TOOLS HERE AT NIH. WE WOULD LIKE I WOULD LIKE
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