Fluoroquinolones and Peripheral Neuropathy
Peripheral neuropathy, this is an often devastatingcondition in which people develop pain and numbness in their hands and feet. Basicallythey're told on the evening news that they should be taking this or that medication sothat they can get through life. That's treating the smoke and ignoring thefire. Those medicines that you're seeing advertised don't treat the neuropathy, they only treatthe symptoms. But what's causing peripheral neuropathy? Well we know that in America,one of the biggest causes of peripheral neuropathy is being diabetic, which is clearly relatedto the foods that you eat by and large. Becoming a type 2 diabetic dramatically increases yourrisk for having peripheral neuropathy and
in fact being devastated by it. This is adisease that effects 1 in 15 Americans. Let's take a look. So again this is 1 in 15 Americansâ€”thisis 20 million Americans afflicted by this disease, that aside from diabetes, we're toldthe cause is unknown. Well maybe that's not exactly true. Last month, in the journal Neurology,an incredible study was published describing a relationship between what are called fluoroquinolones,and the risk of developing a peripheral neuropathy. You may not know what fluoroquinolones are,but chances are you may have actually been exposed to fluoroquinolone. These are antibioticsused for treating things like upper respiratory
infections and even urinary tract infections.Things like Levaquin and Cipro are commonly used in walk in s. If you have a urinarytract infection, you may have received these mediations. Well, here's what the study showedus: So this is a study published in September2014 that looked at men between age 45 to 80 years of age followed for a 10 year periodand in this group there were over 6,000 cases of peripheral neuropathy. And they comparedthese individuals to about 25,000 aged match controls, and what they found was that riskfor developing this devastating condition called peripheral neuropathy was doubled inthose individuals exposed to this class of
antibiotics called fluoroquinolones. And whatthe researchers also told us is that, and I quote, quot;Fluoroquinolones have been shownto neurotoxic. Oral fluoroquinolones have also been associated with reported cases ofpsychosis and seizures, which similar to peripheral neuropathy have been shown to be acute eventsoccurring within days of fluoroquinolone use. In light of strong evidence of unnecessaryprescribing of oral fluoroquinolones in the United States, ians must weigh the riskof PN against the benefits of prescribing FQ when prescribing these drugs to their patients.quot; We've got to practice medicine under the dictumof quot;above all do no harm.quot; One of our most
well respected peer review journals is nowtelling us that the use of these medicationsâ€”these fluoroquinolone antibiotics is associatedwith doubling of the risk of peripheral neuropathy. A disease which often is not treatable. Sokeep that in mind the next time you think you need an antibiotic for this or that problem,discuss this study with your treating physician. I'm David Perlmutter.
How To Reverse Type 2 Diabetes Diabetic Nephropathy
Hello this is Bobpeople are always asking me how I was able to reverse my type 2 diabetes.as a , I knew pretty well how to manage diabetes. As you can imagine, my diet wasstrict. Still, Diabetes was making me feel tired andlethargic all the time. I was taking insulin, my conditions were degenerating over the years.I was even starting to notice a higher levels of albumin in the urine, meaning that my kidneyswhere starting to be affected too. It's a condition called Diabetic Nephropathy.Things weren't going really well. It was a shock for everybody when the newsreported that the quot;professorquot; on which studies
some of our books were based was not evena ! However, as soon as my mind was finally freefrom all those .ahem. misconceptions, it was a lot easier to change things for thebetter. Today, a lot of people and even s!! are still misinformed. How can you tell if your has been teachingyou the lies this fake guru has been spreading?? check the link below.
Diabetic nephropathy Mechanisms
One of the most seriouschronic complications of diabetes mellitus is a condition known as diabetic nephropathy. Which, if you break down the term into nephro and pathy literally means kidney disease that occurssecondary to diabetes. And it's actually pretty common as it eventually affects about20% to 40% of all individuals
with diabetes, includingboth type I and type II. In this tutorial, let'stalk about the mechanism underlying the causeof diabetic nephropathy and how individuals withdiabetes develop the condition. So diabetic nephropathyis a chronic complication of diabetes mellitus. Meaning, it usually has aslow progression over decades after the initial diagnosis of diabetes.
And to give you anoverview of what happens, an insulin deficiency due to the diabetes results in hyperglycemia, which then causes hypertensionand kidney dysfunction. This kidney function isactually then further worsened by the hypertension. And ultimately, all of thisresults in kidney failure, which can have very severeand potentially even
life threateningcomplications, such as anemia, electrolyte imbalances,such as metabolic acidosis, and heart arrhythmias. Now, before we dive into the mechanism of diabetic nephropathy, let'sbriefly review the structure of the glomerulus in the kidney, by bringing in a diagram here. So, the glomerulus isthe portion of the kidney
where blood is initially filtered. So blood enters the glomerulus over here, through this afferent arterial, and then leaves the glomerulus throughthe efferent arterial. And you can remember this, that it leaves throughthe efferent arterial for E for exit, or efferent. And while the blood iswithin the glomerulus,
there's this advanced filtration system, which we'll talk about more in a minute. And the filtered fluidthat exits the blood is known as a filtrate and it collects in Bowman's space before it enters into thetubules of the nephron where further reabsorptionand secretion occurs before it exits the kidneyinto the ureters as urine.